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泛肽通路与细胞凋亡

来源:解剖科学进展
摘要:摘要:泛肽通路的成分包括泛肽、泛肽激活酶、泛肽交联酶、泛肽连接酶和proteasome复合体等。泛肽通路是真核生物选择性降解胞内非正常蛋白质的一种主要途径。一些细胞凋亡过程中有泛肽、泛肽-蛋白质结合物的聚集。proteaosome复合体的结构、功能变化常常发生在程序性细胞死亡的细胞中。...

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  摘 要:泛肽通路的成分包括泛肽、泛肽激活酶、泛肽交联酶、泛肽连接酶和proteasome复合体等。泛肽通路是真核生物选择性降解胞内非正常蛋白质的一种主要途径。一些细胞凋亡过程中有泛肽、泛肽-蛋白质结合物的聚集。proteaosome复合体的结构、功能变化常常发生在程序性细胞死亡的细胞中。p53、bcl-2和ICE等基因对细胞凋亡的调控也与泛肽-proteaosome通路有关。基金项目:国家自然科学基金资助项目 No 39870382参考文献:

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作者: 彭心昭陈英朴英杰 2004-9-29
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